Ctbp-interacting protein
WebThe first CtBP homologue (CtBP1) was identified as a binding partner for the adenoviral transforming protein E1A 6 however CtBP homologues have been implicated as cofactors for a number of cellular transcriptional … WebCtIP is a transcriptional co-regulator that binds a number of proteins involved in cell cycle control and cell development, such as CtBP (Cterminus-binding protein), BRCA1 (breast …
Ctbp-interacting protein
Did you know?
C-terminal-binding protein interacting protein (CtIP) is a binding partner with CtBP, which contribute to transcription repression and cell cycle regulation, and which have a role in the cellular response to DNA damage. Interactions. CTBP1 has been shown to interact with: See more C-terminal-binding protein 1 also known as CtBP1 is a protein that in humans is encoded by the CTBP1 gene. CtBP1 is one of two CtBP proteins, the other protein being CtBP2. See more The CtBP1 protein was originally identified as a human protein that bound a PLDLS motif in the C-terminus of adenovirus E1A proteins. It and the related protein CTBP2 were later shown to … See more • Chinnadurai G (2002). "CtBP, an unconventional transcriptional corepressor in development and oncogenesis". Mol. Cell. 9 (2): 213–24. doi:10.1016/S1097-2765(02)00443-4. PMID 11864595. • Schaeper U, Boyd JM, Verma S, et al. (1995). See more CTBP1 has been shown to interact with: • ACTL6B, • ARF, • EVI1 • FOXP2, • HDAC1, • IKZF1, See more • Human CTBP1 genome location and CTBP1 gene details page in the UCSC Genome Browser. • Overview of all the structural information available in the PDB for See more WebJan 29, 2009 · Recent work from the laboratories of Grossman and Lewis ( 16, 25, 26) indicate that CtBP is a direct target for the Ink4a/Arf tumor suppressor. Attempts to …
WebStructural and Functional Analyses of CtBP. The crystal structures of the N-terminal two-thirds of both human CtBP1/2 (16, 17) and rat CtBP/BARS have been solved, providing … WebMay 22, 2024 · C-terminal Binding Proteins (CtBP1/2) are evolutionarily conserved metazoan transcriptional co-regulators, with the founding paralog CtBP1 initially identified as a phospho-protein that interacted with the C-terminus of the adenovirus E1A protein. 1-3 Extensive genetic studies in model organisms demonstrate that CtBP is required for …
WebMay 1, 2024 · Typical for multivalent adaptor proteins, CtIP contains various short linear sequence motifs facilitating interactions between protein-binding partners, some of which are governed by CtIP phosphorylation (Fig. 1) [2, 24].For instance, CDK-mediated phosphorylation of CtIP at S327 is a prerequisite for the binding of BRCA1 BRCT … WebApr 7, 2024 · The middle HD region is flanked by the Smad interaction domain (SID) and the C-terminal binding protein (CtBP)-interaction domain (CID) . These interaction …
WebOct 17, 2003 · To identify pathways involved in this regulation, we screened a mouse embryo cDNA library with an E1A-CtBP complex and identified the homeodomain …
WebApr 9, 2024 · Data show that retinoblastoma binding protein 8 (CtIP) is a tetrameric protein adopting a dumbbell architecture in which DNA binding domains are connected by long coiled-coils. CtIP is required for faithful replication through telomeres via its roles at stalled replication tracts. brian belichick text to floresWebOct 23, 2024 · Abstract Human C-terminal binding protein (CtBP)-interacting protein (CtIP) is a central regulator to initiate DNA end resection and homologous recombination (HR). Several studies have shown that post-translational modifications control the activity or expression of CtIP. brian bell boxford maWebMar 23, 2024 · A novel C-terminal binding protein (CTBP2) is closely related to CTBP1, an adenovirus E1A-binding protein, and maps to human chromosome 21q21.3. ... Frisch, S. M., Goodman, R. H. Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP. Cell 115: 177-186, 2003. ... brian bell attorneyWebAug 1, 2015 · The CtBP (C-terminal binding protein) interacting protein (CtIP) was initially identified as part of the CtBP transcriptional corepressor complex that mediates repression of many genes and plays important roles in development and cancer [1], [2]. In addition, CtIP was found to bind directly to the retinoblastoma (Rb) protein [3], as well as … couples horoscope for todayWebZEB1 is also having its own protein-interacting domain that shows its affinity toward Smad, CtBP, and p300-p/CAF. In addition, ZEB1 contains E -boxes, which are responsible to bind cofactors. ZEB1 regulates the targeted gene expression both positively and negatively by recruiting its cofactors [47] . couples hotels with private poolsWebJul 3, 2024 · For example, the extracellular signal-regulated kinase (ERK) can phosphorylate MAPK-regulated corepressor-interacting protein 1 (MCRIP1) to keep ZEB1–CtBP repression of gene expression 30. brian belichick wifeWebJul 18, 2003 · Interactions between CtBP and the polycomb repressors have also been reported, but CtBP was not a component of the polycomb complex isolated by Levine et al. . A recent study showed that the association of CtBP with the polycomb protein PC2 led to its sumoylation ( 16 ), but how this modification alters CtBP function is unknown. brian bellairs realtor