WebThe degree of DNA alkylation correlates well with the cytotoxicity of these drugs. The interaction with DNA also accounts for the mutagenic and carcinogenic potential of these drugs. The 7‐nitrogen (N7) and 6‐oxygen (O6) of guanine have been shown to be particularly susceptible to attack by electrophilic compounds. WebAug 28, 2024 · To assess the effect of bulky N7-alkylG on DNA replication, we prepared chemically stable N7-benzylguanine (N7bnG)-containing DNA and evaluated nucleotide …
Cancers Free Full-Text Important Requirements for Desorption ...
WebDive into the research topics of 'Altromycin B Threads the DNA Helix Interacting with Both the Major and the Minor Grooves To Position Itself for Site-Directed Alkylation of Guanine N7'. Together they form a unique fingerprint. altromycin B Medicine & Life Sciences Alkylation Engineering & Materials Science pluramycin Medicine & Life Sciences WebThus, the N7 of guanine and N3 of adenine are the most reactive. The DNA phosphodiester backbone can also undergo an alkylation reaction through interaction of the agent with … st mary\u0027s kingswinford
Nucleophilic properties of purine bases: inherent reactivity versus ...
WebMay 7, 1999 · However, differently from tallimustine, PNU 151807 failed to produce any DNA alkylation as assessed by Taq stop assay and N3 or N7-adenine alkylation assay in different DNA sequences. PNU 151807 ... WebDec 10, 1991 · Results suggest that alkylation occurs primarily at the N-3 rather than N-7 position of adenine, probably as a consequence of the affinity of the aromatic rings of melphalan and chlorambucil for the minor groove. It was previously shown that the predominant mutations induced by melphalan (L-phenylalanine mustard) in the supF … WebApr 23, 2024 · Guanine, Nucleic acid structure Abstract Prodrug treosulfan, originally registered for treatment of ovarian cancer, has gained a use in conditioning prior to hematopoietic stem cell transplantation. Treosulfan … st mary\u0027s kintbury