Web0LQDV *HUDLV GH 0DUoR GH 'LiULR 2ILFLDO GRV 0XQLFtSLRV 0LQHLURV $12 9,,, _ 1 ZZZ GLDULRPXQLFLSDO FRP EU DPP PJ Webil激动剂技术领域.本发明涉及白介素-(il)的变体。特别地,本发明涉及包含人il的突变蛋白或人il的功能性变体的突变蛋白的多肽,其中人il或其功能性变体被替换,使得对βγil受体复合物(ilrβγ)的亲和力增强。在一个实施方案中,人il或其功能性变体还被替换使得对αβγil受体复合物(ilrαβγ)的亲和力 ...
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