WebSep 8, 2024 · NIS ability to concentrate iodine is exploited to treat thyroid tumors and their metastases. Thus, a better understanding of how NIS expression/activity is controlled will help to design strategies to restore radioiodine uptake in RAIR tumors. Multiple mechanisms are responsible for NIS loss of function in thyroid carcinomas (TCs). WebApr 12, 2024 · We investigated the clinical significance of thyroid-stimulating hormone receptor (TSHR) mutations detected in thyroid fine needle aspiration (FNA) ... (NIS) mRNA was in the range of 0.01%–62.43% out of all sequencing reads, and was elevated in 49 (71%) cases. Surgical pathology follow-up was available in five cases (all benign except one). ...
Nutrients Free Full-Text Iodide Excess Inhibits Thyroid Hormone ...
WebOct 12, 2024 · The NIS is a membrane glycoprotein that transports two sodium ions and one iodide ion into the cytosol of benign and tumorous thyroid cells from extracellular fluid (1–3). Since radioiodine also can be taken up by the NIS, radioiodine can be used to visualize or selectively kill DTC cells. WebExpression of the sodium iodide symporter (NIS) is required for efficient iodide uptake in thyroid and lactating breast. Since most differentiated thyroid cancer expresses NIS, β … byers branch library denver
Characterization of the thyroid Na+/I− symporter with an anti …
WebThe rat thyroid model was then extrapolated to humans using human . in vitro . HTS data for NIS inhibition and the chemical specific hepatic clearance rate in humans. The overall species extrapolated PBPK-thyroid kinetics model can be used to predict dose-response (% drop in thyroid serum levels compared to homeostasis) relationships in humans. WebThe rat thyroid model was then extrapolated to humans using human . in vitro . HTS data for NIS inhibition and the chemical specific hepatic clearance rate in humans. The overall … WebFeb 10, 2024 · Active iodide (I-) transport in both the thyroid and some extrathyroidal tissues is mediated by the Na + /I-symporter (NIS). In the thyroid, NIS-mediated I-uptake plays a pivotal role in thyroid hormone (TH) biosynthesis. THs are key during embryonic and … byers brewing company