Phloretin ic50 glut1
WebbPhloretin - CAS 60-82-2 - Calbiochem. A cell-permeable inhibtor of protein kinase C (IC₅₀ = 20-50 µM). WebbKL-11743 is a potent, orally active, and glucose-competitive inhibitor of the class I glucose transporters, with IC50 s of 115, 137, 90, and 68 nM for GLUT1, GLUT2, GLUT3, and GLUT4, respectively. KL-11743 specifically blocks glucose metabolism. KL-11743 can synergize with electron transport inhibitors to induce cell death.
Phloretin ic50 glut1
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Webb7 dec. 2015 · Phloretin/Phlorizin, are very well know Glut1, SGLT1 and SGLT2 inhibitors. These are transporters responsible for transporting glucose into the the cells. For … Webb21 sep. 2024 · The leading compound 6d, the IC50 of which with the GLUT1 inhibitor 4,6-oethylidene-α-D-glucose (EDG) and phloretin (31.80 µM and 38.71 µM) are 36 and 44 folds higher, respectively, than the 48 h IC50 (0.89 µM), ... For cytotoxicity assays, the GLUT1 inhibitors EDG (1) and phloretin (2), the OCT2 inhibitor Ctd.
Webb14 juni 2024 · In addition, phloretin enhanced adipogenesis in GLUT1 knocked-down cells. Taken together, phloretin induced adipogenesis of marrow stromal cells by inhibiting … Webb20 maj 2024 · Phloretin has pleiotropic effects, including glucose transporter (GLUT) inhibition. We previously showed that phloretin promoted adipogenesis of bone marrow stromal cell (BMSC) line ST2 independently of GLUT1 inhibition. This study investigated the effect of phloretin on osteoblastogenesis of ST2 cells and osteoblastic MC3T3-E1 cells.
Webb30 juni 2024 · One well-studied effect of phloretin is the inhibition of glucose transporter 1 (GLUT1) and GLUT 2 [9,10,11]. It has been demonstrated that phloretin inhibits glucose transport across the bovine retinal pigment epithelium (RPE) by 45.5% and that it dose dependently prevents the formation of advanced glycation end products (AGEs) which … Webb1 dec. 2003 · To confirm the specificity of the interaction mediated by GLUT, the cells were pretreated with phloretin, an inhibitor of GLUT-1, before adding RITC-labeled PVG polymer to the cell culture...
WebbResults: The results showed that Phloretin inhibited the proliferation rate of the human SNU-1 gastric cancer cells and showed an IC50 of 18 µM. However, Phloretin showed …
Webb8 aug. 2012 · Other Glut1 inhibitors and glucose transport inhibitors, such as fasentin and phloretin , were also shown to be effective in reducing cancer cell growth. A group of inhibitors of glucose transporters has been recently identified with IC 50 values lower than 20 μmol/L for inhibiting cancer cell growth ( 18 ). by kara henson round table editor-in-chiefWebbBackground: Chronic renal failure (CRF) is associated with increased cardiovascular mortality, and medial vascular smooth muscle cell (VSMC) hypertrophy, proliferation, and calcification play a pivotal role in uremic vasculopathy. Glucose transporter-1 (GLUT1) facilitates the transport of glucose into VSMCs, and GLUT1 overexpression associated … bykare servicesWebbGlucose transporter 1 (GLUT1) serves as a ubiquitously expressed glucose transporter, which could activate inflammatory response by mediating glycolysis. Phloretin (PHL), an … byk altana groupWebbPhloretin also inhibits a variety of urea transporters. [6] [7] It induces urea loss and diuresis when coupled with high protein diets. Phloretin has been found to inhibit weight gain … bykare services ltdWebb12 aug. 2006 · Immunostaining showed that GLUT1 was significantly increased in hypoxic regions of the human colon ... Inhibition of glucose uptake by phloretin sensitized cancer cells to DNR for its anticancer activity and apoptosis to overcome drug ... (IC50 = 50 nM, 44 nM in hypoxia vs. IC50 = 11 and 21 nM in normoxia in SW620 ... byk applicatorWebb(A) After transfection with control or Glut1 siRNA, the cells were incubated in adipogenic medium containing phloretin 0-100 µM, and oil red O staining was performed at day 8. bykare solutionsWebb1 dec. 2024 · Inhibition of GLUT1 via Phloretin was shown to overcome this hypoxia-induced resistance when used in combination with Daunorubicin. Thus, inhibition of glucose uptake by Phloretin sensitized Daunorubicin-resistant SW620 and K562 cancer cells to its anticancer effects and apoptosis by overcoming drug resistance developed … by karisse healing oil